Otto Derolez studied at the Royal Conservatories of Ghent and Brussels, with professors such as Rudolf Werthen, Keti Sbestyen and Philippe Hirschhorn. He graduated from the Internationale Musikakademie für Solisten (IMAS) in Wolfenbüttel (Germany) under the guidance of André Gertler. He also received support and guidance from Yfrah Neaman.
He made his debut with the Brussels Philharmonic in 1999, with Richard Strauss's Ein Heldenleben. With this orchestra he has performed the world premières of violin concertos by Jeroen d'Hoe and Michel Tabachnik, both dedicated to Otto Derolez. His performance of John Williams' Violin Concerto has been highly acclaimed, as well as the Alban Berg Violin Concerto which he performed with Brussels Philharmonic under the baton of Carlos Kalmar.
As a soloist, he has performed in prestigious concert halls all over the world, including the Amsterdam Concertgebouw, Birmingham Symphony Hall, Tokyo Opera City Concert Hall, Festival Hall in Osaka, Cité de la Musique in Paris, just to name a few.